BDBM683770 4-(2-{[(2S,7aR)-2-fluoro- hexahydro-1H-pyrrolizin- 7a-yl]methoxy}-6-chloro- 4-[(1S,6R)-3,9- diazabicyclo[4.2.1]nonan- 3-yl]-8-fluoroquinazolin- 7- yl)naphthalen-2-ol::US20240217982, Example 8-10::US20240217982, Example 8-9

SMILES Oc1cc(-c2c(Cl)cc3c(nc(OC[C@]45CCCN4C[C@@H](F)C5)nc3c2F)N2CC[C@H]3CC[C@@H](C2)N3)c2ccccc2c1

InChI Key InChIKey=ZGKLZERLAXGLEP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 683770   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683770(US20240217982, Example 8-9 | 4-(2-{[(2S,7aR)-2-flu...)
Affinity DataIC50: 5nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683770(US20240217982, Example 8-9 | 4-(2-{[(2S,7aR)-2-flu...)
Affinity DataIC50: 500nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent