BDBM683767 4-(2-{[(2R,7aS)-2-fluoro- hexahydro-1H-pyrrolizin- 7a-yl]methoxy}-6-chloro- 4-[(1S,6R)-3,9- diazabicyclo[4.2.1]nonan- 3-yl]-8-fluoroquinazolin- 7- yl)-5-fluoronaphthalen-2- ol::US20240217982, Example 8-6

SMILES Oc1cc(-c2c(Cl)cc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2CC[C@H]3CC[C@@H](C2)N3)c2c(F)cccc2c1

InChI Key InChIKey=CYIOMOLZSLHZEH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683767   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683767(US20240217982, Example 8-6 | 4-(2-{[(2R,7aS)-2-flu...)
Affinity DataIC50: 70nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
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Date in BDB:
10/11/2024
Entry Details
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