BDBM683765 4-(2-{[(2S,7aR)-2- fluoro-hexahydro-1H- pyrrolizin- 7a-yl]methoxy}-6-chloro- 4-[(1S,6R)-3,9- diazabicyclo[4.2.1]nonan- 3-yl]-8-fluoroquinazolin- 7- yl)-5-ethylnaphthalen-2- ol::US20240217982, Example 8-3::US20240217982, Example 8-4

SMILES CCc1cccc2cc(O)cc(-c3c(Cl)cc4c(nc(OC[C@]56CCCN5C[C@@H](F)C6)nc4c3F)N3CC[C@H]4CC[C@@H](C3)N4)c12

InChI Key InChIKey=MPJJHRZNUYRBDG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 683765   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683765(US20240217982, Example 8-3 | US20240217982, Exampl...)
Affinity DataIC50: 70nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683765(US20240217982, Example 8-3 | US20240217982, Exampl...)
Affinity DataIC50: 7.70E+3nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2024
Entry Details
Go to US Patent