BDBM683761 4-{6-chloro-4-[(1S,6R)-3,9-diazabicyclo[4.2.1]nonan-3-yl]-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}quinazolin-7-yl}naphthalen-2-ol::US20240217982, Example 6

SMILES CN1CCC[C@H]1COc1nc(N2CC[C@H]3CC[C@@H](C2)N3)c2cc(Cl)c(c(F)c2n1)-c1cc(O)cc2ccccc12

InChI Key InChIKey=UWOATYRKMYQEPD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683761   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683761(US20240217982, Example 6 | 4-{6-chloro-4-[(1S,6R)-...)
Affinity DataIC50: 10nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
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Date in BDB:
10/11/2024
Entry Details
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