BDBM683751 4-(6-chloro-4-{3,9-diazabicyclo[4.2.1]nonan-9-yl}-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}quinazolin-7-yl)naphthalen-2-ol::US20240217982, Example 1-1

SMILES CN1CCC[C@H]1COc1nc(N2C3CCC2CNCC3)c2cc(Cl)c(c(F)c2n1)-c1cc(O)cc2ccccc12

InChI Key InChIKey=SILNFBRAMOSIGW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 683751   

TargetGTPase KRas [G12D](Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM683751(US20240217982, Example 1-1 | 4-(6-chloro-4-{3,9-di...)
Affinity DataIC50: 3.33E+4nMAssay Description:Recombinant GDP-loaded KRAS G12D (20 nM) was treated with compound at room temperature for 20 minutes in assay buffer (10 mM Hepes pH 7.4, 150 mM NaC...More data for this Ligand-Target Pair
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Date in BDB:
10/11/2024
Entry Details
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