BDBM682872 2-(2-chlorophenyl)-7- (5,6,7,8- tetrahydroisoquinolin-4- yl)-5,7- diazaspiro[3.4]octane- 6,8-dione::US20240208970, Compound 56

SMILES Clc1ccccc1C1CC2(C1)NC(=O)N(C2=O)C1=CN=CC2CCCCC12

InChI Key InChIKey=HPOVQCNHMVIWJD-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 682872   

TargetReplicase polyprotein 1ab(2019-nCoV)
Individual

US Patent
LigandPNGBDBM682872(US20240208970, Compound 56 | 2-(2-chlorophenyl)-7-...)
Affinity DataIC50: 145nMAssay Description:It was performed in 20 mM Tris, 50 mM NaCl and 0.1 mM EDTA (Merck KGaA, Darmstadt, Germany), pH 7.5 at room temperature. Compounds were transferred w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Individual

US Patent
LigandPNGBDBM682872(US20240208970, Compound 56 | 2-(2-chlorophenyl)-7-...)
Affinity DataKd:  31nMAssay Description:The SPR experiments were performed using a Biacore S200 instrument and CM5 biosensor chips (Cytiva, Uppsala, Sweden) at 25 C. Streptavidin (Sigma) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent