BDBM682871 2-(2-chlorophenyl)-7-(5- fluoroisoquinolin-4-yl)- 5,7- diazaspiro[3.4]octane- 6,8-dione::US20240208970, Compound 53

SMILES Fc1cccc2cncc(N3C(=O)NC4(CC(C4)c4ccccc4Cl)C3=O)c12

InChI Key InChIKey=JYZNLEKBRYQESO-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 682871   

TargetReplicase polyprotein 1ab(2019-nCoV)
Individual

US Patent
LigandPNGBDBM682871(US20240208970, Compound 53 | 2-(2-chlorophenyl)-7-...)
Affinity DataIC50: 253nMAssay Description:It was performed in 20 mM Tris, 50 mM NaCl and 0.1 mM EDTA (Merck KGaA, Darmstadt, Germany), pH 7.5 at room temperature. Compounds were transferred w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Individual

US Patent
LigandPNGBDBM682871(US20240208970, Compound 53 | 2-(2-chlorophenyl)-7-...)
Affinity DataKd:  42nMAssay Description:The SPR experiments were performed using a Biacore S200 instrument and CM5 biosensor chips (Cytiva, Uppsala, Sweden) at 25 C. Streptavidin (Sigma) wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent