BDBM680885 US20240197735, Example AR-31

SMILES Cn1cnc2ccc(Oc3c(Cl)ccc(NS(=O)(=O)N4CCCC4)c3F)cc2c1=O

InChI Key InChIKey=WMZIJTPQPPPLHI-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 680885   

TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680885(US20240197735, Example AR-31)
Affinity DataKd:  45.9nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680885(US20240197735, Example AR-31)
Affinity DataKd:  119nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680885(US20240197735, Example AR-31)
Affinity DataKd:  190nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase CSK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680885(US20240197735, Example AR-31)
Affinity DataKd:  1.21E+3nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
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TargetTyrosine-protein kinase Lck(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680885(US20240197735, Example AR-31)
Affinity DataKd:  1.20E+4nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent