BDBM680882 US20240197735, Example AR-30

SMILES CN(C)S(=O)(=O)Nc1ccc(Cl)c(Oc2ccc3ncn(C)c(=O)c3c2)c1F

InChI Key InChIKey=NMGKGWCKZNTJBE-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 680882   

TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680882(US20240197735, Example AR-30)
Affinity DataKd:  174nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680882(US20240197735, Example AR-30)
Affinity DataKd:  504nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680882(US20240197735, Example AR-30)
Affinity DataKd:  822nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase CSK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680882(US20240197735, Example AR-30)
Affinity DataKd:  8.01E+3nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM680882(US20240197735, Example AR-30)
Affinity DataKd:  1.04E+4nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent