BDBM680880 US20240199525, Compound BPDA2

SMILES CCCCCCCCCOc1ccc(cc1C(O)=O)-c1ccc(CC(O)=O)cc1

InChI Key InChIKey=ZNUFCVFEZWEKRQ-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 680880   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 92nMAssay Description:Inhibition of SHP2 (unknown origin) PTPase activity using DiFMUP as substrate incubated for 20 mins by fluorescence plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 92nMAssay Description:Inhibition of SHP2 (unknown origin) PTPase activity using DiFMUP as substrate in presence of 1 nM enzyme incubated for 20 mins by fluorescence plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 135nMAssay Description:Inhibition of SHP2 (unknown origin) PTPase activity using DiFMUP as substrate in presence of 2.5 nM enzyme incubated for 20 mins by fluorescence plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 237nMAssay Description:Inhibition of SHP2 (unknown origin) PTPase activity using DiFMUP as substrate in presence of 5 nM enzyme incubated for 20 mins by fluorescence plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 47nMAssay Description:Inhibition of SHP2 (unknown origin) PTPase activity using pNPP as substrate in presence of 1 nM enzyme incubated for 1 hr by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 69nMAssay Description:Inhibition of SHP2 (unknown origin) PTPase activity using pNPP as substrate in presence of 2.5 nM enzyme incubated for 2 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 103nMAssay Description:Inhibition of SHP2 (unknown origin) PTPase activity using pNPP as substrate in presence of 5 nM enzyme incubated for 3 hrs by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 3.34E+4nMAssay Description:Inhibition of GST-tagged SHP1 PTP domain (unknown origin) using DiFMUP as substrate incubated for 20 mins by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibition of PTP1B (unknown origin) using DiFMUP as substrate incubated for 20 mins by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 4.07E+4nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 92nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 3.34E+4nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM680880(US20240199525, Compound BPDA2)
Affinity DataIC50: 92nMAssay Description:First, the GST fusion of the PTP domains of SHP2, SHP1, and PTP1B were produced and purified as reported by us previously.32 The reactions were perfo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent