BDBM679680 US20240182487, Compound 81

SMILES CN(C)CCNC(=O)c1ccc2\C=C\c3n[nH]c4cnc(cc34)-c3cnn(C)c3COCCOc2c1

InChI Key InChIKey=RELRGQAKSBATCK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 679680   

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM679680(US20240182487, Compound 81)
Affinity DataIC50: 14.1nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM679680(US20240182487, Compound 81)
Affinity DataIC50: 28.1nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM679680(US20240182487, Compound 81)
Affinity DataIC50: 40.1nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM679680(US20240182487, Compound 81)
Affinity DataIC50: 94.6nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
US Patent