BDBM679676 US20240182487, Compound 75

SMILES COC(=O)c1ccc2OCCOCc3c(cnn3C)-c3cc4c(\C=C\c2c1)n[nH]c4cn3

InChI Key InChIKey=VYSHKSMRMXRCHL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 679676   

TargetEpidermal growth factor receptor [L858R](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM679676(US20240182487, Compound 75)
Affinity DataIC50: 165nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM679676(US20240182487, Compound 75)
Affinity DataIC50: 184nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM679676(US20240182487, Compound 75)
Affinity DataIC50: 51nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Blossomhill Therapeutics

US Patent
LigandPNGBDBM679676(US20240182487, Compound 75)
Affinity DataIC50: 938nMAssay Description:Biochemical Assays for Inhibition of Wild-Type and Mutant EGFRs.The inhibitory activities against EGFR WT, EGFR Δ752-759 mutant, EGFR Δ746-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
Go to US Patent