BDBM678119 N-(1-cyclobutyl-3- cyclopropyl-1H- pyrazol-4-yl)-2-(1- methyl-1H-pyrazol- 4-yl)-1,3-thiazole-4- carboxamide::US20240174679, Example 12-2

SMILES Cn1cc(cn1)-c1nc(cs1)C(=O)Nc1cn(nc1C1CC1)C1CCC1

InChI Key InChIKey=HVUJGONQSRVZQN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678119   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM678119(US20240174679, Example 12-2 | N-(1-cyclobutyl-3- c...)
Affinity DataIC50: 17.4nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
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