BDBM678118 Scheme 23. Synthesis of N-(1-(cyclobutylmethyl)-1H-pyrazol-4-yl)-2-(1-methyl-1H-pyrazol-4-yl)thiazole-4-carboxamide::US20240174679, Example 12-1

SMILES Cn1cc(cn1)-c1nc(cs1)C(=O)Nc1cnn(CC2CCC2)c1

InChI Key InChIKey=KMKLRLHIYPNNGZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678118   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM678118(US20240174679, Example 12-1 | Scheme 23. Synthesis...)
Affinity DataIC50: 18.2nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
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Date in BDB:
9/5/2024
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