BDBM678071 Scheme 19. Synthesis of N-(1-(2-methylpyridin-4-yl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)thiazole-4-carboxamide::US20240174679, Example 8-1

SMILES Cc1cc(ccn1)-n1cc(NC(=O)c2csc(n2)-c2cn[nH]c2)cn1

InChI Key InChIKey=XIVPIPAFBZNBRT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678071   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM678071(US20240174679, Example 8-1 | Scheme 19. Synthesis ...)
Affinity DataIC50: 12.6nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
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Date in BDB:
9/5/2024
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