BDBM678044 N-[1-(4- fluorobenzyl)- 1H-pyrazol-4- yl]-2-(1H- pyrazol-4-yl)- 1,3-thiazole-4- carboxamide::US20240174679, Example 7-17

SMILES Fc1ccc(Cn2cc(NC(=O)c3csc(n3)-c3cn[nH]c3)cn2)cc1

InChI Key InChIKey=CSGIJDYOBKIUMK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678044   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM678044(US20240174679, Example 7-17 | N-[1-(4- fluorobenzy...)
Affinity DataIC50: 17.4nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent