BDBM678036 N-[3- (difluoromethyl)- 1-(2- fluoroethyl)-1H- pyrazol-4-yl]-2- (1H-pyrazol-4- yl)-1,3-thiazole- 4-carboxamide::US20240174679, Example 7-9

SMILES FCCn1cc(NC(=O)c2csc(n2)-c2cn[nH]c2)c(n1)C(F)F

InChI Key InChIKey=WXHWBASRGRXFCP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678036   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM678036(US20240174679, Example 7-9 | N-[3- (difluoromethyl...)
Affinity DataIC50: 17.8nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent