BDBM678028 Scheme 18. Synthesis of N-(1-(cyclobutylmethyl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)thiazole-4-carboxamide::US20240174679, Example 7-1

SMILES O=C(Nc1cnn(CC2CCC2)c1)c1csc(n1)-c1cn[nH]c1

InChI Key InChIKey=GCMJUXXZIQFNHK-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678028   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent

LigandBDBM678028(US20240174679, Example 7-1 | Scheme 18. Synthesis ...)Copy SMILESCopy InChI

Affinity DataIC50: 17.4nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/5/2024
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