BDBM678008 Scheme 15. Synthesis of N-(1-cyclopropyl-1H-pyrazol-4-yl)-6-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)picolinamide::US20240174679, Example 4-1

SMILES FC(F)(F)Cn1cc(cn1)-c1cccc(n1)C(=O)Nc1cnn(c1)C1CC1

InChI Key InChIKey=ZUAMDENPDAOUKB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678008   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM678008(US20240174679, Example 4-1 | Scheme 15. Synthesis ...)
Affinity DataIC50: 10.5nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
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Date in BDB:
9/5/2024
Entry Details
US Patent