BDBM678004 N-(1-cyclobutyl- 3-cyclopropyl- 1H-pyrazol-4- yl)-2-(1H- pyrazol-4-yl)- 1,3-thiazole-4- carboxamide::US20240174679, Example 3-2

SMILES O=C(Nc1cn(nc1C1CC1)C1CCC1)c1csc(n1)-c1cn[nH]c1

InChI Key InChIKey=OALKPEMASDCFAS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 678004   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM678004(US20240174679, Example 3-2 | N-(1-cyclobutyl- 3-cy...)
Affinity DataIC50: 4.47nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
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