BDBM677971 US20240174679, Example 1-19::methyl 1-methyl- 4-({[2-(1H- pyrazol-4-yl)- 1,3-thiazol-4- yl]carbonyl} amino)-1H- pyrazole-3- carboxylate

SMILES COC(=O)c1nn(C)cc1NC(=O)c1csc(n1)-c1cn[nH]c1

InChI Key InChIKey=IJZQCXXAFCNOKV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 677971   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM677971(US20240174679, Example 1-19 | methyl 1-methyl- 4-(...)
Affinity DataIC50: 2.19nMAssay Description:IC50 (half-maximal inhibitory concentration) represents the concentration of inhibitor required to inhibit LRRK2 kinase activity by 50%. Assays were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent