BDBM677074 (3R)-N-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide::US20240174621, Example 1

SMILES Cn1cnc2ccc(Oc3c(F)ccc(NS(=O)(=O)N4CC[C@@H](F)C4)c3C#N)cc2c1=O

InChI Key InChIKey=ZUXPFTYMSHPRQX-UHFFFAOYSA-N

Data  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 677074   

TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  0.600nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  1.20nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  1.70nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase CSK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  2.33E+4nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  4.00E+4nMAssay Description:Kd is measured using surface plasmon resonance assays using a BIACORER-2000 or a BIACORE-3000 (BIAcore, Inc., Piscataway, NJ) at 25 C. with immobiliz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  0.600nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  1.20nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  1.70nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase CSK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  2.33E+4nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Lck(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM677074(US20240174621, Example 1 | (3R)-N-[2-cyano-4-fluor...)
Affinity DataKd:  4.00E+4nMAssay Description:The assay is not in detail.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2024
Entry Details
Go to US Patent