BDBM677057 N-(4-((6-aniline-1H- pyrazolo[3,4-d]pyrimidin-1- yl)methyl)phenyl)but-2- enamide::US11993603, Example 25

SMILES C\C=C\C(=O)Nc1ccc(Cn2ncc3cnc(Nc4ccccc4)nc23)cc1

InChI Key InChIKey=DUDOUIYUWQWBGN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 677057   

TargetTyrosine-protein kinase JAK3(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677057(US11993603, Example 25 | N-(4-((6-aniline-1H- pyra...)
Affinity DataIC50: 1.20nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677057(US11993603, Example 25 | N-(4-((6-aniline-1H- pyra...)
Affinity DataIC50: 1.04E+3nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM677057(US11993603, Example 25 | N-(4-((6-aniline-1H- pyra...)
Affinity DataIC50: 2.40E+3nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent