BDBM676912 US20240166665, Example 002

SMILES C[C@@H]1CCCOc2c(cnn2C)-c2sc(cc2NC(=O)C=C)C(=O)Nc2nc3ccc(Br)cc3n2C1

InChI Key InChIKey=GEKPJTUIAHCDJA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 676912   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM676912(US20240166665, Example 002)
Affinity DataIC50: 100nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio). Inhibitors and DMSO n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM676912(US20240166665, Example 002)
Affinity DataIC50: 100nMAssay Description:EGFR biochemical activity measurements were carried out using the homogeneous time-resolved fluorescence (HTRF) assay (Cisbio). Inhibitors and DMSO n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
Go to US Patent