BDBM676801 US20240166660, Compound A32::US20240166660, Compound B2

SMILES Clc1cccc2cccc(-c3cc4ncnc(N5CCN([C@@H](CC#N)C5)C(=O)C=C)c4c4OCCCc34)c12

InChI Key InChIKey=FFFASMOPJQABHU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 676801   

TargetGTPase KRas [G12C,C51S,C80L,C118S](Human)
BeiGene Switzerland GmbH

US Patent
LigandPNGBDBM676801(US20240166660, Compound A32 | US20240166660, Compo...)
Affinity DataIC50: 12nMAssay Description:The KRAS (aa 1-169) G12C, C51S, C80L, C118S with a His-tag was expressed, purified and loaded with GDP in house. All protein and substrate solutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C,C51S,C80L,C118S](Human)
BeiGene Switzerland GmbH

US Patent
LigandPNGBDBM676801(US20240166660, Compound A32 | US20240166660, Compo...)
Affinity DataIC50: 2.24E+3nMAssay Description:The KRAS (aa 1-169) G12C, C51S, C80L, C118S with a His-tag was expressed, purified and loaded with GDP in house. All protein and substrate solutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent