BDBM676798 US20240166660, Compound A29

SMILES Clc1cc2[nH]ncc2c(c1Cl)-c1cc2ncnc(N3CCN([C@@H](CC#N)C3)C(=O)C=C)c2c2OCCCc12

InChI Key InChIKey=LSDFWOMLXPQQEZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 676798   

TargetGTPase KRas [G12C,C51S,C80L,C118S](Human)
BeiGene Switzerland GmbH

US Patent
LigandPNGBDBM676798(US20240166660, Compound A29)
Affinity DataIC50: 9.30nMAssay Description:The KRAS (aa 1-169) G12C, C51S, C80L, C118S with a His-tag was expressed, purified and loaded with GDP in house. All protein and substrate solutions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent