BDBM676760 2-[(3R,8R)-2,5-dioxa-10,16,18-triazatetracyclo[9.7.0.0{}{3,8}.0{}{13,17}]octadeca-1(11),12,14,17-tetraen-10-yl]-4-{2-[(2S)-2-(2-methylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl}-N-{3-nitro-4-[(oxan-4-ylmethyl)amino]benzenesulfonyl}benzamide::US20240166646, Example 68

SMILES Cc1ccccc1[C@@H]1CCCN1C1CC2(C1)CCN(CC2)c1ccc(C(=O)NS(=O)(=O)c2ccc(NCC3CCOCC3)c(c2)[N+]([O-])=O)c(c1)N1C[C@H]2CCOC[C@@H]2Oc2nc3[nH]ccc3cc12

InChI Key InChIKey=MHIGBXSJOUPLTN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 676760   

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM676760(2-[(3R,8R)-2,5-dioxa-10,16,18-triazatetracyclo[9.7...)
Affinity DataIC50: 0.303nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
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Date in BDB:
8/26/2024
Entry Details
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