BDBM676722 2-[(11R,15S)-13,16-dioxa-2,4,10-triazatetracyclo[7.7.0.0{}{3,7}.0{}{11,15}]hexadeca-1(9),2,5,7-tetraen-10-yl]-4-{2-[(2S)-2-(2-fluorophenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl}-N-{3-nitro-4-[(oxan-4-ylmethyl)amino]benzenesulfonyl}benzamide::US20240166646, Example 24

SMILES [O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1N1[C@@H]2COC[C@H]2Oc2nc3[nH]ccc3cc12)N1CCC2(CC(C2)N2CCC[C@H]2c2ccccc2F)CC1

InChI Key InChIKey=KPHVPKCSEQSCDD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 676722   

TargetApoptosis regulator Bcl-2(Human)
Newave Pharmaceutical

US Patent
LigandPNGBDBM676722(2-[(11R,15S)-13,16-dioxa-2,4,10-triazatetracyclo[7...)
Affinity DataIC50: 0.420nMAssay Description:The fluorescence-labeled 23 amino acid peptide BH3 was purchased from CalBiochem (NLWAAQRYGRELRRMSDKFVD). An unbound Fluorescein labeled BH3 peptide ...More data for this Ligand-Target Pair
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Date in BDB:
8/26/2024
Entry Details
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