BDBM676342 US20240166635, Example 63

SMILES Cn1ccc(n1)S(=O)(=O)N1CCC(CC1)Nc1ncc(C#N)c(OCC2(C)CCCC2)n1

InChI Key InChIKey=MVTRGLCCCNTBRI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 676342   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandPNGBDBM676342(US20240166635, Example 63)
Affinity DataIC50: 10nMAssay Description:CDK1/CyclinB kinase inhibitory activity (IC50): 5 μl of various dilutions of test compound in 1×kinase buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandPNGBDBM676342(US20240166635, Example 63)
Affinity DataIC50: 10nMAssay Description:CDK2/CyclinE1 kinase inhibitory activity (IC50): 5 μl of various dilutions of test compounds in 1×kinase buffer (50 mM HEPES pH 7.5, 10 mM MgCl2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandPNGBDBM676342(US20240166635, Example 63)
Affinity DataIC50: 10nMAssay Description:CDK4/CyclinD1 kinase inhibitory activity (IC50): 5 l of various dilutions of test compound in 1×kinase buffer (20 mM HEPES, pH 7.5, 10 mM MgCl2, 2 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandPNGBDBM676342(US20240166635, Example 63)
Affinity DataIC50: 10nMAssay Description:CDK6/CyclinD1 kinase inhibitory activity (IC50): 5 l of various dilutions of test compound in 1×kinase buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, 2 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandPNGBDBM676342(US20240166635, Example 63)
Affinity DataIC50: 550nMAssay Description:CDK7/Cyclin HIMAT1 kinase inhibitory activity (IC50): 5 l of various dilutions of test compound in 1×kinase buffer (20 mM HEPES, pH 7.5, 10 mM MgCl2,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Anrui Biomedical Technology (Guangzhou) Co.

US Patent
LigandPNGBDBM676342(US20240166635, Example 63)
Affinity DataIC50: 550nMAssay Description:CDK9/CyclinT1 kinase inhibitory activity (IC50): 5 l of various dilutions of test compound in 1×kinase buffer (20 mM HEPES, pH 7.5, 10 mM MgCl2, 2 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent