BDBM676207 1-(1-Acetyl-7-fluoro-4-isopropyl-2-(o-toly1)-1,2,3,4-tetrahydroquinolin-6-y1)-4- ethyl-3-(hydroxymethyl)-1H-1,2,4-triazol-5(4H)-one::US20240166622, Example 24

SMILES CCn1c(CO)nn(-c2cc3C(CC(N(C(C)=O)c3cc2F)c2ccccc2C)C(C)C)c1=O

InChI Key InChIKey=LVAWUNHMNBIDKY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 676207   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676207(US20240166622, Example 24 | 1-(1-Acetyl-7-fluoro-4...)
Affinity DataIC50: 5.53E+3nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent