BDBM676196 4-Ethyl-2-((3S*,4R*)-6-fluoro-4-hydroxy-1-isopropyl-3-(o-toly1)-1,2,3,4- tetrahydroquinolin-7-yl)-5-(hydroxymethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one::US20240166622, Example 17

SMILES CCn1c(CO)nn(-c2cc3N(C[C@@H]([C@@H](O)c3cc2F)c2ccccc2C)C(C)C)c1=O

InChI Key InChIKey=XMTDFWUSFMTOQV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 676196   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676196(US20240166622, Example 17 | 4-Ethyl-2-((3S*,4R*)-6...)
Affinity DataIC50: 173nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
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Date in BDB:
8/26/2024
Entry Details
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