BDBM676128 4-Ethyl-2-((3S*,4S*)-6-fluoro-4-hydroxy-1-isopropyl-3-(o-tolyl)-1,2,3,4- tetrahydroquinolin-7-yl)-5-(hydroxymethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one::US20240166622, Example 15

SMILES CCn1c(CO)nn(-c2cc3N(C[C@@H]([C@H](O)c3cc2F)c2ccccc2C)C(C)C)c1=O

InChI Key InChIKey=XMTDFWUSFMTOQV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 676128   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM676128(US20240166622, Example 15 | 4-Ethyl-2-((3S*,4S*)-6...)
Affinity DataIC50: 7.90nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent