BDBM675069 (S)-4-(trifluoromethyl)-5-((1-((5-(5-(5-(trifluoromethyl)pyrimidin-2-yl)-4,5,6,7-tetrahydro pyrazolo[1,5-a]pyrazin-2-yl)methoxy)propan-2-yl)amino)pyridazin-3(2H)-one ::US20240158406, Compound 1

SMILES C[C@@H](COCc1cc2CN(CCn2n1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F

InChI Key InChIKey=MGVXZPZERCYIKA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 675069   

TargetPoly [ADP-ribose] polymerase 1(Human)
Chengdu Baiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM675069((S)-4-(trifluoromethyl)-5-((1-((5-(5-(5-(trifluoro...)
Affinity DataIC50: 1.00E+3nMAssay Description:This assay adopted PARP1, TNKS1, TNKS2, PARP7 and PARP14 chemiluminescence detection kits (BPS, Cat No. 80551/80552/80573/80578/79729/80568) for enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
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TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Chengdu Baiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM675069((S)-4-(trifluoromethyl)-5-((1-((5-(5-(5-(trifluoro...)
Affinity DataIC50: 1.00E+4nMAssay Description:This assay adopted PARP1, TNKS1, TNKS2, PARP7 and PARP14 chemiluminescence detection kits (BPS, Cat No. 80551/80552/80573/80578/79729/80568) for enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Chengdu Baiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM675069((S)-4-(trifluoromethyl)-5-((1-((5-(5-(5-(trifluoro...)
Affinity DataIC50: 1.00E+4nMAssay Description:This assay adopted PARP1, TNKS1, TNKS2, PARP7 and PARP14 chemiluminescence detection kits (BPS, Cat No. 80551/80552/80573/80578/79729/80568) for enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP14(Human)
Chengdu Baiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM675069((S)-4-(trifluoromethyl)-5-((1-((5-(5-(5-(trifluoro...)
Affinity DataIC50: 1.00E+4nMAssay Description:This assay adopted PARP1, TNKS1, TNKS2, PARP7 and PARP14 chemiluminescence detection kits (BPS, Cat No. 80551/80552/80573/80578/79729/80568) for enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
Chengdu Baiyu Pharmaceutical Co.

US Patent
LigandPNGBDBM675069((S)-4-(trifluoromethyl)-5-((1-((5-(5-(5-(trifluoro...)
Affinity DataIC50: 30nMAssay Description:This assay adopted PARP1, TNKS1, TNKS2, PARP7 and PARP14 chemiluminescence detection kits (BPS, Cat No. 80551/80552/80573/80578/79729/80568) for enzy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent