BDBM674372 Racemic 4-Ethyl-2-(7-fluoro-4-isopropyl-2-(o-tolyl)-1,2,3,4-tetrahydroquinolin- 6-yl)-5-(hydroxymethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one::US20240166622, Example 13

SMILES CCn1c(CO)nn(-c2cc3C(CC(Nc3cc2F)c2ccccc2C)C(C)C)c1=O

InChI Key InChIKey=RSLPGUPZQYLANY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674372   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674372(US20240166622, Example 13 | Racemic 4-Ethyl-2-(7-f...)
Affinity DataIC50: 51.7nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
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Date in BDB:
8/26/2024
Entry Details
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