BDBM674350 3-(2-Chloro-6-fluorophenyl)-7-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro- 1H-1,2,4-triazol-1-y1)-6-fluoro-1-isopropylquinolin-4(1H)-one::US20240166622, Example 12

SMILES CCn1c(CO)nn(-c2cc3n(cc(-c4c(F)cccc4Cl)c(=O)c3cc2F)C(C)C)c1=O

InChI Key InChIKey=PFDVHQQXCAWGRR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674350   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674350(US20240166622, Example 12 | 3-(2-Chloro-6-fluoroph...)
Affinity DataIC50: 20nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
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Date in BDB:
8/26/2024
Entry Details
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