BDBM674347 7-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-y1)-6- fluoro-1-isopropyl-3-(o-tolyl)quinolin-4(1H)-one::US20240166622, Example 10

SMILES CCN1C(=NN(C1=O)c2cc3c(cc2F)C(=O)C(=CN3C(C)C)c4ccccc4C)CO

InChI Key InChIKey=KFGUDADAEJZXDC-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674347   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674347(US20240166622, Example 10 | 7-(4-Ethyl-3-(hydroxym...)
Affinity DataIC50: 7.59nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
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Date in BDB:
8/26/2024
Entry Details
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PDB3D3D Structure (crystal)