BDBM674345 (R*)-1-(2-(2-Chloro-6-fluorophenyl)-7-fluoro-4-isopropyl-3,4-dihydro-2H- benzo[b][1,4]oxazin-6-y1)-4-ethyl-3-(hydroxymethyl)-1H-1,2,4-triazol-5(4H)- one::US20240166622, Example 8

SMILES CCn1c(CO)nn(-c2cc3N(C[C@H](Oc3cc2F)c2c(F)cccc2Cl)C(C)C)c1=O

InChI Key InChIKey=PXEOUHCBTWMXHI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674345   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674345(US20240166622, Example 8 | (R*)-1-(2-(2-Chloro-6-f...)
Affinity DataIC50: 5.5nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
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Date in BDB:
8/26/2024
Entry Details
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