BDBM674344 (S*)-1-(2-(2-Chloro-6-fluorophenyl)-7-fluoro-4-isopropyl-3,4-dihydro-2H- benzo[b][1,4]oxazin-6-yl)-4-ethyl-3-(hydroxymethyl)-1H-1,2,4-triazol-5(4H)- one::US20240166622, Example 7

SMILES CCn1c(CO)nn(-c2cc3N(C[C@@H](Oc3cc2F)c2c(F)cccc2Cl)C(C)C)c1=O

InChI Key InChIKey=PXEOUHCBTWMXHI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674344   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674344(US20240166622, Example 7 | (S*)-1-(2-(2-Chloro-6-f...)
Affinity DataIC50: 0.256nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent