BDBM674342 2-(2-Chloro-6-fluorophenyl)-6-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro- 1H-1,2,4-triazol-1-yl)-7-fluoro-4-isopropyl-2H-benzo[b][1,4]oxazin-3(4H)-one::US20240166622, Example 5

SMILES CCn1c(CO)nn(-c2cc3N(C(C)C)C(=O)C(Oc3cc2F)c2c(F)cccc2Cl)c1=O

InChI Key InChIKey=QDYFLVKRHCULJG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674342   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674342(US20240166622, Example 5 | 2-(2-Chloro-6-fluorophe...)
Affinity DataIC50: 42.3nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
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Date in BDB:
8/26/2024
Entry Details
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