BDBM674341 2-(2-(2-Chloro-6-fluorophenyl)-4-((S)-1,1,1-trifluoropropan-2-y1)-1,2,3,4- tetrahydroquinoxalin-6-yl)-4-ethyl-5-(hydroxymethyl)-2,4-dihydro-3H-1,2,4- triazol-3-one::US20240166622, Example 4

SMILES CCn1c(CO)nn(-c2ccc3NC(CN([C@@H](C)C(F)(F)F)c3c2)c2c(F)cccc2Cl)c1=O

InChI Key InChIKey=XXEKJFSYLZMBPS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674341   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674341(US20240166622, Example 4 | 2-(2-(2-Chloro-6-fluoro...)
Affinity DataIC50: 2.42nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
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Date in BDB:
8/26/2024
Entry Details
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