BDBM674340 3-(2-Chloro-6-fluorophenyl)-7-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro- 1H-1,2,4-triazol-1-yl)-1-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroquinoxalin- 2(1H)-one::US20240166622, Example 3

SMILES CCn1c(CO)nn(-c2ccc3NC(C(=O)N([C@@H](C)C(F)(F)F)c3c2)c2c(F)cccc2Cl)c1=O

InChI Key InChIKey=VVMLHYZPKAOXHW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674340   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674340(US20240166622, Example 3 | 3-(2-Chloro-6-fluorophe...)
Affinity DataIC50: 293nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
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