BDBM674339 7-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-y1)-3-(2- (methylthio)phenyl)-1-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroquinoxalin- 2(1H)-one::US20240166622, Example 2

SMILES CCn1c(CO)nn(-c2ccc3NC(C(=O)N([C@@H](C)C(F)(F)F)c3c2)c2ccccc2SC)c1=O

InChI Key InChIKey=IBAXWSZPYITJNF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674339   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech, Inc.

US Patent
LigandPNGBDBM674339(US20240166622, Example 2 | 7-(4-Ethyl-3-(hydroxyme...)
Affinity DataIC50: 588nMAssay Description:To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent