BDBM674289 3,5-difluoro-4- hydroxy-N- ({(1r,4r)-4-[6-(5- methoxypyridin-3-yl)- 2H-indazol-2- yl]cyclohexyl}methyl) benzamide, trifluoroacetate salt::US20240150334, Example 120

SMILES COc1cncc(c1)-c1ccc2cn(nc2c1)[C@H]1CC[C@H](CNC(=O)c2cc(F)c(O)c(F)c2)CC1

InChI Key InChIKey=KJTRLTSVYCHSTR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 674289   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Pfizer

US Patent
LigandPNGBDBM674289(3,5-difluoro-4- hydroxy-N- ({(1r,4r)-4-[6-(5- meth...)
Affinity DataIC50: 6.5nMAssay Description:HSD17B13 uses the oxidized form of nicotinamide adenine dinucleotide (NAD+) as a cofactor during metabolism of beta-estradiol (substrate), converting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent