BDBM670824 (6R)-3-(5-(difluoromethoxy)-2- fluorophenyl)-1-(1,1- difluoropropan-2-yl)-N-(3-methyl- 1,1-dioxidothietan-3-yl)-4,5,6,7- tetrahydro-1H-indazole-6- carboxamide (faster eluting with OD-H column, 20% iPrOH/CO2)::US20240140938, Example 48a::US20240140938, Example 48b

SMILES CC(C(F)F)n1nc(c2CC[C@H](Cc12)C(=O)NC1(C)CS(=O)(=O)C1)-c1cc(OC(F)F)ccc1F

InChI Key InChIKey=GMGVNENTQHNBGF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 670824   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670824((6R)-3-(5-(difluoromethoxy)-2- fluorophenyl)-1-(1,...)
Affinity DataIC50: 19.8nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM670824((6R)-3-(5-(difluoromethoxy)-2- fluorophenyl)-1-(1,...)
Affinity DataIC50: 90.3nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product 13C18-triolein (13C-1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
US Patent