BDBM670759 5-[[(3S,4S)-1-[3-ethyl-7-(ethylamino)-5-fluoro-2-oxo-indolin-3-yl]-4-fluoro-3-piperidyl]amino]pyridine-2-carbonitrile::US20240140933, Example 49

SMILES CCNc1cc(F)cc2c1NC(=O)C2(CC)N1CCC(F)[C@H](C1)Nc1ccc(nc1)C#N

InChI Key InChIKey=XBSQLHPVYDSVRU-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 670759   

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Hoffmann-La Roche

US Patent

LigandBDBM670759(5-[[(3S,4S)-1-[3-ethyl-7-(ethylamino)-5-fluoro-2-o...)Copy SMILESCopy InChI

Affinity DataIC50: 16nMAssay Description:The inhibitory potency of compounds of PDHK1 activity was determined in an enzymatic assay. Pyruvate dehydrogenase complex (PDHc) is an enzyme that c...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
7/25/2024
Entry Details
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