BDBM670578 (S)-1-(3-(1-amino-1′-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-1,3-dihydrospiro[indene-2,4′-piperidin]-6-yl)prop-2-yn-1-yl)urea::US20240140931, Compound 159

SMILES COc1ccc(CN(CC#Cc2ccc3CC4(CCN(CC4)c4cnc(Sc5ccnc(N)c5Cl)c(N)n4)[C@H](N[S@](=O)C(C)(C)C)c3c2)C#N)cc1

InChI Key InChIKey=SAPMROBXSGSJSA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 670578   

LigandPNGBDBM670578((S)-1-(3-(1-amino-1′-(6-amino-5-((2-amino-3-...)
Affinity DataIC50: 1nMAssay Description:1. Reagents and MaterialsHuman full-length SHP2 recombinant protein: BPS Bioscience, Cat #79018;SHP2 substrate DiFMUP (1 mM): BPS Bioscience, Cat #79...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
Go to US Patent