BDBM670470 (S)-6-(1-amino-6-ethynyl-1,3-dihydrospiro[indene-2,4′-piperidin]-1′-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3H)-one::US20240140931, Compound 12

SMILES Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1CCC2(Cc3ccc(cc3[C@H]2N[S@](=O)C(C)(C)C)C#C[Si](C)(C)C)CC1

InChI Key InChIKey=GDNVHRTXWJCHGY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 670470   

LigandPNGBDBM670470((S)-6-(1-amino-6-ethynyl-1,3-dihydrospiro[indene-2...)
Affinity DataIC50: 1nMAssay Description:1. Reagents and MaterialsHuman full-length SHP2 recombinant protein: BPS Bioscience, Cat #79018;SHP2 substrate DiFMUP (1 mM): BPS Bioscience, Cat #79...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2024
Entry Details
Go to US Patent