BDBM669998 US20240132525, Example 048

SMILES OB1OCc2cc(Nc3ncc(Cl)c(NC4COCCC4C#N)n3)cc(Cl)c12

InChI Key InChIKey=QJHBABAGVNTWQU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 669998   

TargetTyrosine-protein kinase JAK1(Human)
Boehringer Ingelheim Animal Health Usa

US Patent
LigandPNGBDBM669998(US20240132525, Example 048)
Affinity DataIC50: 0.600nMAssay Description:Reagent: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij 35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO, where r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Boehringer Ingelheim Animal Health Usa

US Patent
LigandPNGBDBM669998(US20240132525, Example 048)
Affinity DataIC50: 15.6nMAssay Description:Reagent: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij 35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO, where r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent