BDBM669939 US20240132525, Example 009

SMILES Cc1cc(Nc2ncc(C)c(NC3CCCCC3C#N)n2)cc2COB(O)c12

InChI Key InChIKey=AUYNOHWMKXOEKM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 669939   

TargetTyrosine-protein kinase JAK1(Human)
Boehringer Ingelheim Animal Health Usa

US Patent
LigandPNGBDBM669939(US20240132525, Example 009)
Affinity DataIC50: 1.10nMAssay Description:Reagent: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij 35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO, where r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Boehringer Ingelheim Animal Health Usa

US Patent
LigandPNGBDBM669939(US20240132525, Example 009)
Affinity DataIC50: 13.8nMAssay Description:Reagent: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij 35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO, where r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent