BDBM669891 US12129258, Example 1::US20240132517, Comparative Compound 42

SMILES C[C@H]1COC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23

InChI Key InChIKey=VGEDWONGQUXJQA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 669891   

TargetHepatocyte growth factor receptor(Human)
Goharmony Therapeutics (Shenzhen) Co.

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 85nMAssay Description:The operation method is briefly described as follows:The powders of the compound were dissolved in 100% DMSO to make a 10 mM stock solution. The init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Goharmony Therapeutics (Shenzhen) Co.

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 289nMAssay Description:The operation method is briefly described as follows:The powders of the compound were dissolved in 100% DMSO to make a 10 mM stock solution. The init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
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TargetMacrophage colony-stimulating factor 1 receptor(Human)
Goharmony Therapeutics (Shenzhen) Co.

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 1.00E+4nMAssay Description:The operation method is briefly described as follows:The powders of the compound were dissolved in 100% DMSO to make a 10 mM stock solution. The init...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
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TargetHigh affinity nerve growth factor receptor(Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 0.130nMAssay Description:Based on HTRF of Cisbio (Cisbio, Cat. 08-52) principle, TRKA and ALK-L1196M kinase activity detection platform were established to determine the inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
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TargetALK tyrosine kinase receptor [L1196M](Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 50nMAssay Description:Based on HTRF of Cisbio (Cisbio, Cat. 08-52) principle, TRKA and ALK-L1196M kinase activity detection platform were established to determine the inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
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TargetHigh affinity nerve growth factor receptor(Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 0.420nMAssay Description:Based on HTRF of Cisbio (Cisbio, Cat. 08-52) principle, TRKA and ALK-L1196M kinase activity detection platform were established to determine the inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
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TargetBDNF/NT-3 growth factors receptor(Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 0.5nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
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TargetNT-3 growth factor receptor(Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 0.610nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
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TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 0.330nMAssay Description:The compound powder was dissolved in 100% DMSO (Sigma, Cat. D8418-1l) to prepare a 10 mM storage solution. The compounds had an initial test concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
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TargetProto-oncogene tyrosine-protein kinase ROS [G2032R](Human)
Primegene (Beijing)

US Patent
LigandPNGBDBM669891(US20240132517, Comparative Compound 42 | US1212925...)
Affinity DataIC50: 0.360nMAssay Description:Based on LanceUltra (Perkin Elmer, CR97-100) principle, ROS1-G2032R kinase activity detection platform was established to determine the inhibitory ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2025
Entry Details
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